Rotary motion of DNA rotors on nanopores. Major row: Uncooked video of your Cy5 channel of every rotor. Center row: corresponding solitary-particle localization results of both equally ends with the DNA rotors. The place of the present frame is marked as orange and blue dots, and the trajectory of The ten frames before The present body is proven as good traces.

Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination purpose.

Multicolor imaging of the bacterial nucleoid and cell division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins

Due to the fact 2000, Dekker has shifted the most crucial aim of his do the job to biophysics where by he experiments the properties of one biomolecules and cells utilizing the instruments of nanotechnology. This variation of subject was pushed by his fascination for the exceptional operating of Organic molecular buildings, and because of the very long-phrase perspective that many attention-grabbing discoveries is often predicted On this field.[5] Recent traces of research in his biophysics team are inside the areas of:[six]

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Instance (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim on the pore is highlighted in crimson, in addition to a 3D rendering with the motion of your DNA rod is shown.

Given that 2000 he moved to single-molecule biophysics and nanobiology, with research from DNA supercoiling experiments of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Not too long ago his study has centered on learning cell division with bacteria on chip, when his supreme curiosity is in the course of recognizing artificial cells.

Atomic drive microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA in the cooperative fashion

‘Indeed, I understand men and women were stunned at some time. At the end of the nineties, Once i was in my forties, I had been Professor of Molecular Electronics and I have to confess that it experienced become a bit bored, I didn’t master Significantly anymore. The field went a lot more into the applying side, how you might combine nanotubes into electronic circuits.

Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding as being the action-making course of action

An built-in microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

Many new phenomena ended up identified, and he and his analysis team established a leading place On this industry of exploration. Dekker and his study team identified new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they ended up the very first to develop a transistor depending on only one nanotube molecule.

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2013, managed shaping of Dwell bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes